Seneca Buffalo Creek Casino is a Native American casino in Buffalo, New York and is open daily 24 hours. Buffalo Creek Casino in Buffalo, New York. Come here to have fun! The 2 established casinos in Buffalo (Buffalo Creek Seneca Casino and Buffalo Casino & Raceway Hamburg) naturally have an array of slot machines on top of. Visit Seneca Buffalo Creek Casino for thrilling gaming, sports betting and great restaurants. Akwesasne Mohawk Casino, Hogansburg · State Route 37 ; Buffalo Raceway Hamburg Gaming, Hamburg · South Park Avenue ; Casino Empire City Yonkers. Enjoy drinks and cocktails at choice of bars. - See traveler reviews, candid photos. Seneca Niagara Resort & Casino: Probably the best casino + hotel choice in the Niagara Falls area. We offer over 80 tables of live-action gaming plus more than 2, slot machines. If you're seeking the thrill of the game, Seneca Niagara is the place for you. Seneca Buffalo Creek Casino in Buffalo, NY features over slot machines, table games, great restaurants, and a laidback vibe. Top 10 Best Casinos Near Buffalo, New York · Seneca Buffalo Creek Casino · Seneca Niagara Resort & Casino · Hamburg Fairgrounds · Casino Niagara · Buffalo Creek. Complete casino information including address, telephone number, map, gaming tables, slot machines. Just blocks from Canalside, HarborCenter, the Cobblestone District, KeyBank Center, Coca-Cola® Field, the Theatre District, Larkin Square and all other. . The casino's 67, square foot gaming space.